NATURE MATERIALS: Scientists Found a New Way to Rapidly Cast the Patterned Vascular Networks

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Nature - Materials Science magazine recently reported a general vascular rapid prototyping methods, the method is the use of carbohydrates vitreous as expendable templates, enabling the formation of the vascular network in the design of human tissue. The method or stent for maintaining the functions in the design of body tissue can be in certain physiological density is increased proportionally and used as therapeutic alternatives.

If there is no The vascular network transport nutrients and oxygen, as well as metabolic byproducts, the organization will soon produce necrotic cells and hinder the running of the organization function. Covered perspective vascular tissue but cultured in the laboratory, the process is slow and complex, and the desired material and the cell types are usually also limited.

Christopher Chen et al use 3D printing technology as well as a mixture of glucose and sucrose, the establishment of a glass long-fiber network, and the cell suspension was mixed with the living body populate extracellular matrix. Matrix crosslinking, the researchers dissolved the long fiber washed off, leaving many of the channels formed by the long fiber, these channels is ultimately required for blood vessels.

The researchers also demonstrated that the method can be applied to many types of cells, extracellular matrix and crosslinking, and the use of the method can be achieved independent control of the vascular network geometry and cell types - whether it is in the endovascular or vascular .


《自然—材料学》杂志最近报道了一种通用的血管快速成型方法,该法利用碳水化合物玻璃体作为可消耗模板,从而实现在所设计的人体组织中形成血管网。该方法或可使设计出的人体组织中用于维持功能的支架在一定生理密度下按比例增大,并被用作治疗替代物。


如果没有血管网络运送养分、氧气以及代谢副产物,组织将很快产生坏死细胞,阻碍组织功能的运行。但要在实验室中培养出布满立体血管的组织,其过程是缓慢而复杂的,且所需的材料和细胞种类通常也受到限制。


Christopher Chen等人利用3D打印技术以及葡萄糖和蔗糖的混合物,建立了一种玻璃长纤维网络并将其与活体细胞悬浮液混合填入细胞外基质中。在基质发生交联后,研究人员将其中的长纤维溶解洗掉,留下许多由长纤维形成的通道,这些通道便是最终所需的血管。


研究人员还证明了该方法可适用于许多种类的细胞、细胞外基质和交联方式,并且利用该方法可以实现对血管网络几何形状和细胞种类的独立控制——不管是在血管内还是血管间。

原文链接:http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3357.html



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